AB203. SOH26AB_0152. Oesophageal manifestations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): a St. James’s Hospital experience
General Surgery Posters I

AB203. SOH26AB_0152. Oesophageal manifestations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): a St. James’s Hospital experience

Richard Gaule, Jessie Elliott

Department of Upper Gastrointestinal Surgery, St. James’s Hospital, Dublin, Ireland

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic autoimmune disorder caused by pathogenic variants in the AIRE gene. Although chronic mucocutaneous candidiasis is a hallmark of the disease, involvement of the oesophagus is increasingly recognised as a significant source of morbidity. Reported manifestations range from chronic candidal oesophagitis to immune-mediated oesophagitis and structuring disease, yet the prevalence, clinical patterns, and diagnostic features of oesophageal involvement remain poorly defined. Real-world data from clinical practice are limited, and systematic characterisation of these complications is needed to inform surveillance and management. This study aimed to examine the spectrum of oesophageal disease in patients with APECED at St. James’s Hospital.

Methods: We will be conducting a retrospective review of patients’ electronic medical records with genetically or clinically confirmed APECED followed at our hospital. Electronic medical records will be examined for demographic data, clinical features, endoscopic findings, histopathology, microbiology, imaging, treatments, and outcomes related to oesophageal disease.

Results: Although data collection is ongoing, we expect this study to provide a clearer understanding of oesophageal disease in APECED and highlight under-recognised clinical patterns. The results will contribute to improved surveillance strategies and may inform future therapeutic approaches.

Conclusions: This study will provide real-world data on the spectrum of oesophageal involvement in APECED and aims to inform diagnostic strategies and management approaches. Findings will help address current knowledge gaps and guide future multicentre studies.

Keywords: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED); candidiasis; oesophagitis; oesophagus; stricture

Acknowledgments

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Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-26-ab203
Cite this abstract as: Gaule R, Elliott J. AB203. SOH26AB_0152. Oesophageal manifestations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): a St. James’s Hospital experience. Mesentery Peritoneum 2026;10:AB203.

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