AB203. SOH26AB_0152. Oesophageal manifestations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): a St. James’s Hospital experience

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic autoimmune disorder caused by pathogenic variants in the AIRE gene. Although chronic mucocutaneous candidiasis is a hallmark of the disease, involvement of the oesophagus is increasingly recognised as a significant source of morbidity. Reported manifestations range from chronic candidal oesophagitis to immune-mediated oesophagitis and structuring disease, yet the prevalence, clinical patterns, and diagnostic features of oesophageal involvement remain poorly defined. Real-world data from clinical practice are limited, and systematic characterisation of these complications is needed to inform surveillance and management. This study aimed to examine the spectrum of oesophageal disease in patients with APECED at St. James’s Hospital.