AB135. SOH25_AB_026. A quality-of-life meta-analysis comparing pre- and post-operative symptoms in women undergoing colorectal resection for deep infiltrating endometriosis

Background: Deep infiltrating endometriosis (DIE) may involve the rectum or colon and is associated with pain, gastrointestinal dysfunction and reduced quality of life (QoL). While hormonal treatment may be effective, surgical intervention including colorectal resection can be required. Colorectal resection can result in functional changes and complications which can also impair QoL. This study examines all available comparative pre- and post-operative data on QoL and symptom outcomes following colorectal resection for DIE.

Methods: An electronic database search was conducted for studies reporting pre- and post-operative QoL and symptom outcomes following colorectal resection for DIE. The study was registered with PROSPERO and followed Preferred Reporting Items in Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data was combined using random-effects models.

Results: A total of 14 studies including 1,142 patients were included. Colorectal resection was associated with improved outcomes for all items in the SF-36 QoL questionnaire as well as symptom outcomes including dysmenorrhoea, chronic pelvic pain and deep dyspareunia. Importantly, gastrointestinal QoL index was significantly improved [mean difference, 24.50; 95% confidence interval (CI): 15.93 to 33.08; P<0.0001] as was dyschezia (mean difference, −4.1; 95% CI: −4.77 to −3.42; P<0.0001). There was no change in low anterior resection syndrome scores (mean difference, −5.28; 95% CI: −11.65 to 1.10; P=0.1046).

Conclusions: This study demonstrates a significant post-operative improvement in patient reported QoL, pain symptoms and gastrointestinal function following colorectal resection for endometriosis.

Keywords: Deep infiltrating endometriosis (DIE); colorectal resection; quality of life (QoL); low anterior resection syndrome; gastrointestinal function