AB118. SOH25_AB_086. Evaluating the impact of BRCA alterations on long-term survival outcomes in patients with male breast cancer—a systematic review and meta-analysis
Systematic Reviews Session

AB118. SOH25_AB_086. Evaluating the impact of BRCA alterations on long-term survival outcomes in patients with male breast cancer—a systematic review and meta-analysis

Youssef Guirguis, Matthew Davey, Eman Suliman, Ellen Boyle, Julliette Buckley, Chwanrow Baban, Brigid Anne Merrigan, Shona Tormey

Department of Surgery, University Hospital Limerick, Limerick, Ireland

Background: The impact of breast cancer gene (BRCA) alteration on the survival outcomes in female breast cancer has been established. The association between BRCA alteration on overall survival (OS) in male breast cancer (MBC) remain uncertain. This study aimed to perform a systematic review and meta-analysis evaluating the impact of BRCA alterations on long-term OS outcomes in patients with MBC.

Methods: A systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. An electronic database search was conducted of the PubMed, Embase, and Scopus. Dichotomous variables were pooled as odds ratios (ORs) with associated 95% confidence interval (CI) using the Mantel-Haenszel method using RevMan version 5.4. Subgroup analysis was performed for the follow-up durations.

Results: Six studies including 442 patients were included (median age of 64.6 years; range, 58–68 years). Of these, 243 patients were tested for BRCA alteration, 77% of them tested positive. Overall patients with sporadic breast cancers were more likely to have a longer overall 5-year survival (OR =0.27; 95% CI: 0.10–0.70; P=0.007). However, 10-year survival did not reach statistical significance (OR =0.3; 95% CI: 0.06–1.48; P=0.14).

Conclusions: Male patients being treated for breast cancer with BRCA alterations had poorer survival outcomes. Thus, robust screening for BRCA alterations may be indicated to enhance diagnosis and further personalise treatment strategies in accordance with these findings.

Keywords: Breast cancer gene (BRCA); breast cancer in men; male breast cancer (MBC); survivor analysis; systematic review

Acknowledgments

None.

Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-25-ab118
Cite this abstract as: Guirguis Y, Davey M, Suliman E, Boyle E, Buckley J, Baban C, Merrigan BA, Tormey S. AB118. SOH25_AB_086. Evaluating the impact of BRCA alterations on long-term survival outcomes in patients with male breast cancer—a systematic review and meta-analysis. Mesentery Peritoneum 2025;9:AB118.

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