AB040. SOH25_AB_380. Risk of gastric adenocarcinoma in those with gastric atrophy: a systematic review
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AB040. SOH25_AB_380. Risk of gastric adenocarcinoma in those with gastric atrophy: a systematic review

Eoghan Burke1, Patricia Harkins2, Sarah Fenn3, Mayilone Arumugasamy1

1Department of Surgery, Beaumont Hospital, Beaumont, Dublin, Ireland; 2Department of Medicine, St James’s Hospital, Saint James, Dublin, Ireland; 3Department of Surgery, Mater Misericordiae University Hospital, Phibsborough, Dublin, Ireland

Background: Gastric atrophy (GA) is a pre-neoplastic lesion in the development of gastric cancer (GC), progressing through the Correa cascade from chronic gastritis to intestinal-type gastric adenocarcinoma. Despite this known pathway, the exact risk of GC development in individuals with GA remains uncertain, complicating decisions regarding the need and intervals for surveillance.

Methods: This systematic review was conducted in accordance with PRISMA guidelines, aggregating studies that evaluated the risk of GC in individuals with GA.

Results: We included 18 studies with a total of 25,455 patients. The relative risk (RR) of GC in patients with GA was found to be 15.1, with a 95% confidence interval of 13.5 to 16.9, based on standardized incidence ratios. This risk is comparable to that observed in non-dysplastic Barrett’s esophagus.

Conclusions: Our findings suggest that GA significantly increases the risk of developing GC, possibly more than previously recognized. However, further large-scale studies, particularly in Western populations, are needed to more precisely quantify this risk and inform surveillance strategies. Future research should standardize the assessment of GA, including factors like Helicobacter pylori status, GA distribution, and grading.

Keywords: Gastric; adenocarcinoma; atrophy

Acknowledgments

None.

Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-25-ab040
Cite this abstract as: Burke E, Harkins P, Fenn S, Arumugasamy M. AB040. SOH25_AB_380. Risk of gastric adenocarcinoma in those with gastric atrophy: a systematic review. Mesentery Peritoneum 2025;9:AB040.

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