AB038. SOH25_AB_344. The prognosis of breast cancer patients with solitary or oligometastatic bone disease supports resecting the primary
Clinical Breast

AB038. SOH25_AB_344. The prognosis of breast cancer patients with solitary or oligometastatic bone disease supports resecting the primary

Gerard Hill1,2, Aisling Hegarty2, Gavin Dowling2, Sandra Hembrecht2, Trudi Roche2, Eithne Downey2, Michael Allen2, Colm Power2, Nuala Healy2, Arnold Hill2

1Department of Surgery, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland; 2Beaumont Royal College of Surgeons in Ireland Cancer Centre, Beaumont Hospital, Dublin, Ireland

Background: While systemic therapy in combination with radiotherapy remains the cornerstone of treatment for patients with stage IV breast cancer, particularly those with bone metastases, the role of surgical intervention on the primary breast lesion remains controversial. This study aims to evaluate survival outcomes in patients with single and oligometastatic bone metastases.

Methods: This retrospective cohort study analysed data from 4,000 breast cancer patients treated between 2006 and 2024. Patients were evaluated for bone metastases, which were confirmed through imaging reviewed via the Picture Archiving and Communication System (PACS). Patients with confirmed bone metastases were categorized into solitary, oligometastatic (2–5 sites), or multiple metastases groups. Data on demographics, tumour characteristics, treatment regimens, surgery types, and survival outcomes were collected. Survival analyses were conducted using Kaplan-Meier curves and compared using log-rank tests.

Results: A total of 187 patients with metastatic bone disease were identified. Twenty-one patients had solitary bone metastases only with a mean survival of 14.6 years. Additionally, 30 patients had oligometastatic bone disease only with a mean survival of 7 years. Another 31 patients had multiple bone only metastases, with also a mean survival of 7 years. Finally, 105 of the 187 patients had other metastases alongside bone metastases in other organs including the lung, liver, and brain with a mean survival of 6.3 years.

Conclusions: Surgery on the primary tumour in breast cancer patients should be considered in patients diagnosed with bone-only metastases, as survival outcomes are highly favourable.

Keywords: Bone metastasis; breast cancer; resecting; surgery; survival

Acknowledgments

None.

Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-25-ab038
Cite this abstract as: Hill G, Hegarty A, Dowling G, Hembrecht S, Roche T, Downey E, Allen M, Power C, Healy N, Hill A. AB038. SOH25_AB_344. The prognosis of breast cancer patients with solitary or oligometastatic bone disease supports resecting the primary. Mesentery Peritoneum 2025;9:AB038.

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