AB015. SOH25_AB_277. Comparing transurethral resection of the prostate, holmium laser enucleation of the prostate and thulium laser enucleation of the prostate in medium sized prostates: a systematic review and network meta-analysis of randomised control trials
Urology Session

AB015. SOH25_AB_277. Comparing transurethral resection of the prostate, holmium laser enucleation of the prostate and thulium laser enucleation of the prostate in medium sized prostates: a systematic review and network meta-analysis of randomised control trials

Jelizaveta Cvetkova1, Gavin Calpin1, Stefanie Croghan2, Niall Davis1

1Department of Urology, Beaumont Hospital, Dublin, Ireland; 2Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland

Background: Transurethral resection of the prostate (TURP) is the gold standard treatment for benign prostatic hyperplasia (BPH) in medium-sized prostates. Recently, holmium laser enucleation of the prostate (HoLEP) and thulium laser enucleation of the prostate (ThuLEP) have been used to treat BPH. We aimed to evaluate the perioperative, uroflowmetry, sexual and quality of life outcomes of TURP, HoLEP and ThuLEP in medium-sized prostates.

Methods: A systematic review conducted in accordance with PRISMA for Network Meta-Analyses (PRISMA-NMA) guidelines.

Results: Six randomised control trials were included with a total of 811 patients. Patient characteristics were comparable between groups. There was no difference between operative time. HoLEP and ThuLEP were associated with shorter length of stay compared to TURP. At 6 months post-operatively, a reduced International Prostate Symptom Score (IPSS) was noted in HoLEP and ThuLEP compared to TURP. HoLEP was associated with reduced IPSS at 1 year. Sexual and quality of life parameters were comparable between treatment modalities.

Conclusions: HoLEP and ThuLEP are associated with a shorter length of stay and lower IPSS at 6 months compared to TURP. IPSS was lower and Qmax (i.e., fastest flow rate) was higher in HoLEP compared to TURP at 1 year.

Keywords: Laser enucleation; meta-analysis; prostatic hyperplasia; transurethral resection; treatment outcomes

Acknowledgments

None.

Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-25-ab015
Cite this abstract as: Cvetkova J, Calpin G, Croghan S, Davis N. AB015. SOH25_AB_277. Comparing transurethral resection of the prostate, holmium laser enucleation of the prostate and thulium laser enucleation of the prostate in medium sized prostates: a systematic review and network meta-analysis of randomised control trials. Mesentery Peritoneum 2025;9:AB015.

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