General Surgery Session II
AB112. SOH24AB_199. Soft tissue sarcoma: experience of a national tertiary referral centre over a ten-year period
Nicola Raftery1,2, Muhammad Umair1,2, Una Hayden1,3, Amy Gillis3, Paul Ridgway1,2,3
1Department of Surgery, Tallaght University Hospital, Tallaght, Dublin, Ireland;
2Trinity College at Tallaght University Hospital, University of Dublin, Dublin, Ireland;
3St Vincent’s Sarcoma Ireland Network (SSIN), St. Vincent’s University Hospital, Dublin, Ireland
Background: The incidence and demographic profile of patients with soft tissue sarcomas of the torso (STSt) in Ireland is poorly delineated in the literature to date. This study investigates the epidemiology of STSt within a prominent national tertiary referral network. Analysing patient demographics, histological subtypes, and treatment modalities, this research aims to enhance our understanding of STSt prevalence and management trends, particular after international recent paradigm shifts in care.
Methods: A retrospective cohort study of a cancer database at a St Vincent’s Sarcoma Ireland Network (SSIN) referral centre was performed. Demographic data, histopathological reports, and treatment regimens were analysed. Descriptive statistics and regression models were employed to elucidate epidemiological and treatment patterns.
Results: All patients referred to 2018 with a sarcomatoid diagnosis were included. In total, 90 patients, made up of 56% females and 44% males with a median age of 60 were included. Across all referrals, 63% were patients living outside of Dublin spanning 17 counties. The most common tumour sites were retroperitoneal (39%), abdominopelvic (26%) and groin (14%). Histological subtypes included leiomyosarcoma (19%), well-differentiated liposarcoma (10%), dedifferentiated liposarcoma (8%). Neoadjuvant treatment was given to 17% of patients independent of age (mean difference <1 year, P=0.81). Tumours were deemed resectable in 90% of cases. Of those resected, 97.8% achieved R0/1 margins with a mean tumour size of 11.5 cm (range: 2.1–39 cm; resected versus non resected, P=0.12). Minimum follow-up time recorded for patients was 18 months. Of this cohort, 48% are alive without disease.
Conclusions: The study highlights treatment trends are based on disease factors and not size (technical) or age (patient factors). Survival trends and treatment approaches are favourably compared to international standards.
Keywords: Adjuvant; demographics; neoadjuvant; soft tissue sarcoma; surgery
Acknowledgments
Funding: None.
Conflicts of Interest: The authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
doi: 10.21037/map-24-ab112
Cite this abstract as: Raftery N, Umair M, Hayden U, Gillis A, Ridgway P. AB112. SOH24AB_199. Soft tissue sarcoma: experience of a national tertiary referral centre over a ten-year period. Mesentery Peritoneum 2024;8:AB112.
