AB108. SOH24AB_101. A retrospective cohort study comparing dual-isotope aubtraction SPECT/CT with dual phase SPECT/CT for preoperative localization before parathyroidectomy
General Surgery Session II

AB108. SOH24AB_101. A retrospective cohort study comparing dual-isotope aubtraction SPECT/CT with dual phase SPECT/CT for preoperative localization before parathyroidectomy

Louise Kent, Sarah Keyes, Sadhbh O’Connor, Michael Moore, Youssef Al-Mukhaizeem, Henry Redmond, Bernadette O’Flynn, Abeera Mehmood, Hilal Al Harthi, Sharjeel Paul

Department of Surgery, Cork University Hospital, Wilton, Cork, Ireland

Background: The gold standard treatment for primary hyperparathyroidism is parathyroidectomy. Preoperative localization of parathyroid adenomas enables minimally invasive surgery. The aim of this study was to directly compare the diagnostic accuracy of dual-isotope subtraction single-photon emission computed tomography/computed tomography (SPECT/CT) with dual phase SPECT/CT for localization of abnormal parathyroid glands in patients with primary hyperparathyroidism. While a number of studies have reviewed the accuracy of these preoperative modalities independently, few have directly compared their sensitivity and specificity.

Methods: We conducted a single centre retrospective cohort study including patients who underwent dual isotope SPECT/CT or dual phase SPECT/CT and parathyroidectomy for primary hyperparathyroidism in Cork University Hospital from July 2022 to July 2023. We analyzed the reports of their radiological scans and assessed concordance with final pathological reports.

Results: A total of 54 patients were included in this study. Twenty-seven underwent dual-isotope subtraction SPECT/CT and 27 underwent dual phase SPECT/CT. Sensitivity of dual isotope scanning was 72% while sensitivity of dual phase imaging was 46%. Specificity of both modalities was 100%. Fourteen of 27 lateralized correctly on dual-isotope imaging while 11 of 27 lateralized correctly on dual phase imaging. Eleven of 27 localized correctly on dual isotope while 3 of 27 localized correctly on dual phase imaging.

Conclusions: Although a small number of patients were included in this study, dual isotope imaging was more specific than dual phase imaging for parathyroid disease. Dual isotope imaging was also a superior modality for lateralizing and localizing parathyroid disease. Further studies should include larger cohorts to confirm these findings.

Keywords: Dual-isotope; localization; radiology; parathyroidectomy; primary hyperparathyroidism

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-24-ab108
Cite this abstract as: Kent L, Keyes S, O’Connor S, Moore M, Al-Mukhaizeem Y, Redmond H, O’Flynn B, Mehmood A, Al Harthi H, Paul S. AB108. SOH24AB_101. A retrospective cohort study comparing dual-isotope aubtraction SPECT/CT with dual phase SPECT/CT for preoperative localization before parathyroidectomy. Mesentery Peritoneum 2024;8:AB108.

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