AB027. SOH24AB_074. Evaluating the association between body mass indices and the 21-gene recurrence score: a systematic review and network meta-analysis
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AB027. SOH24AB_074. Evaluating the association between body mass indices and the 21-gene recurrence score: a systematic review and network meta-analysis

Ciara Hunt1, Matthew Davey2, Alisha Jaffer1,2, Ryan Wilson1,2, Juliette Buckley1, Chwanrow Baban2, Bridget Anne Merrigan2, Shona Tormey2

1School of Medicine, University of Limerick, Castletroy, Limerick, Ireland; 2Symptomatic Breast Unit, University Hospital Limerick, Dooradoyle, Limerick, Ireland

Background: Obesity has been associated with a propensity to develop estrogen receptor positive (ER+) cancers. There is limited data assessing the impact of body mass index (BMI) on 21-gene recurrence score (RS) results. This study aims to perform a systematic review and network meta-analysis (NMA) evaluating if low BMI is associated with lower RS in ER breast cancer.

Methods: A systematic review was performed as per Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Descriptive statistics were used as appropriate. Meta analysis was performed using the Mantel-Haenszel method using RevMan v5.4 and NMA using shiny.

Results: Six studies with 3,523 patients were included. The mean age was 61 years, mean RS was 16.6, respectively. Using traditional RS cut-offs 66.4% had a RS <18 (3,529/5,312), 27% had RS 18–30 (1,466/5,412) and 6% had a RS of >30 (317/5,312). At meta-analysis, patients with RS 18–30 [risk ratio (RR): 1.15, 95% confidence interval (CI): 0.91–1.46] and RS >30 (RR: 1.03, 95% CI: 0.79–1.35) were not associated with lower BMI. Using TAILORx cut offs, 24.2% had a RS <11 (996/4,124), 63.1% (2,604/4,124) had a RS 11–25 and 12.7% had a RS >25 (524/4,124). At meta-analysis, patients with RS 11–25 (RR: 1.57, 95% CI: 0.77–3.75) and RS >25 (RR 1.58, 95% CI: 0.71–3.77) were also not associated with lower BMI.

Conclusions: This study failed to identify a significant association between BMI and RS group.

Keywords: Body mass index (BMI); breast cancer; cancer genomics; personal medicine; surgical oncology

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-24-ab027
Cite this abstract as: Hunt C, Davey M, Jaffer A, Wilson R, Buckley J, Baban C, Merrigan BA, Tormey S. AB027. SOH24AB_074. Evaluating the association between body mass indices and the 21-gene recurrence score: a systematic review and network meta-analysis. Mesentery Peritoneum 2024;8:AB027.

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