AB056. SOH23ABS_126. Physical activity and frailty as part of health related quality of life assessment in oesophageal cancer survivors following oesophagectomy
Plenary Session

AB056. SOH23ABS_126. Physical activity and frailty as part of health related quality of life assessment in oesophageal cancer survivors following oesophagectomy

Ellen Boyle, Jessie Elliott, Christine Greene, Conor Murphy, Noel Donlon, Claire Donohoe, Narayasamy Ravi, John Reynolds

Department of Upper Gastrointestinal Surgery, St James Hospital, Dublin, Ireland

Background: Survival rates for patients with oesophageal cancer are improving resulting in an increasing population of oesophageal cancer survivors. Surgery is the mainstay of treatment which has a high risk of post-operative morbidity. This study aimed to characterise health related quality of life in oesophageal cancer survivors following curative oesophagectomy with a specific focus on physical activity and frailty assessment.

Methods: This was a cross-sectional cohort study of patients who underwent oesophageal cancer surgery between 2010 and 2015. A multicomponent questionnaire was distributed to disease-free patients at least one year post completion of treatment. Linear and logistic regression analyses were utilised to determine the impact of treatment and pathologic variables on physical activity and frailty.

Results: On multivariable analysis, age was a significant predictor of level of physical activity (P=0.001). Male sex, critical care length of stay and eating symptoms were independent predictors of frailty in both the PRISMA7 and SARCF tools (all P<0.001). Inpatient length of stay (P<0.001) and persistent eating symptoms following treatment (P<0.001) were both predictive of physical function following completion of treatment.

Conclusions: Curative oesophagectomy can have significant effects on patients’ physical function, levels of physical activity and risk of frailty. Current methods of assessing health related quality of life in oesophageal cancer survivorship may under-investigate the effects of curative oesophagectomy on physical activity and frailty. Further research is warranted to investigate how patient pathways can be enhanced to minimise the long-term health related quality of life (HR-QL) impact of curative treatment.

Keywords: Health related quality of life (HR-QL); frailty; oesophagectomy; oesophageal cancer survivorship; physical activity

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-23-ab056
Cite this abstract as: Boyle E, Elliott J, Greene C, Murphy C, Donlon N, Donohoe C, Ravi N, Reynolds J. AB056. SOH23ABS_126. Physical activity and frailty as part of health related quality of life assessment in oesophageal cancer survivors following oesophagectomy. Mesentery Peritoneum 2023;7:AB056.

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