AB009. SOH22ABS142. OncotypeDX© use in patients diagnosed with early-stage estrogen receptor positive breast cancer
Clinical Breast Session

AB009. SOH22ABS142. OncotypeDX© use in patients diagnosed with early-stage estrogen receptor positive breast cancer

James Phelan, Matthew Davey, Ray McLaughlin, Karl Sweeney, Carmel Malone, Michael Barry, Maccon Keane, Aoife Lowery, Michael Kerin

Department of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, Galway, Ireland

Background: Estrogen receptor positive (ER+) breast cancer is the most common breast cancer molecular subtype. In recent times, the OncotypeDX© Recurrence Score (RS) predicts response to chemoendocrine therapies in early-stage ER+ breast cancers.

Methods: Consecutive female patients diagnosed with ER+, human epidermal growth factor receptor-2 negative, lymph node negative (ER+/HER2−/LN−) breast cancer managed in a single institution between 2005–2015 were included. RS testing was assessed using descriptive statistics. Survival analyses were performed using log-rank Kaplan Meier analyses for disease-free survival (DFS) and overall survival (OS).

Results: A total of 358 patients underwent RS testing, with a mean RS 18.6±8.1 (range, 3–59). The mean follow up was 84.1 months. Overall, 85.5% of patients had RS <25 (306/358), of whom 199 received adjuvant chemotherapy (65.0%). Fourteen and a half percent had RS >25 (52/358) and 44 received adjuvant chemotherapy (84.6%, 44/52). RS group (RS <25 versus RS >25) failed to predict DFS or OS in this cohort (P=0.458). Receiving adjuvant chemotherapy failed to enhance DFS for those with RS <25 (P=0.588) and for those with RS >25 (P=0.438). Furthermore, receiving adjuvant chemotherapy failed to enhance OS for those with RS <25 (P=0.588) and for those with RS >25 (P=0.438). All patients received adjuvant endocrine therapy (100%, 358/358).

Conclusions: RS testing is useful in predicting those who will benefit from chemoendocrine therapy in early-stage ER+/HER2−/LN−. Patient substratification is crucial to personalise treatment specific to each patient.

Keywords: Breast; cancer; estrogen; oncotype; score

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-22-ab009
Cite this abstract as: Phelan J, Davey M, McLaughlin R, Sweeney K, Malone C, Barry M, Keane M, Lowery A, Kerin M. AB009. SOH22ABS142. OncotypeDX© use in patients diagnosed with early-stage estrogen receptor positive breast cancer. Mesentery Peritoneum 2022;6:AB009.

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