AB110. SOH21AS201. Reproductive hormone levels in patients with severe obesity undergoing bariatric surgery
General Session II

AB110. SOH21AS201. Reproductive hormone levels in patients with severe obesity undergoing bariatric surgery

Mary Ann Ryan1, Emma Kearns2, Naomi Fearon3, Tim McMackin1, Cian Lawton1, Pauric O’Reilly2, Helen Heneghan3

1UCD Health Sciences Centre, University College Dublin, School of Medicine, Dublin, Ireland; 2Department of Surgery, St. Vincent’s University Hospital, Dublin, Ireland; 3Department of Surgery, St. Vincent’s University Hospital, National Bariatric Centre, Dublin, Ireland

Background: Severe obesity is associated with altered levels of reproductive hormones, which has potential implications for an individual’s fertility and cancer risk. The aim of this study was to assess the prevalence of obesity-associated gonadal dysfunction in a cohort of Irish patients with severe obesity.

Methods: Patients with severe obesity [body mass index (BMI) >30 kg/m2] undergoing preparation for bariatric surgery over a 3-year period were included in this study. Their preoperative data were prospectively collected, including patient demographics, preoperative weight and obesity complications. Hormonal assays included total testosterone, oestradiol and sex hormone binding globulin (SHBG).

Results: A total of 128 patients were included. The majority of patients were female (70.3%, n=90). The mean age (±SD) of males and females was 51.1±9.7 and 48.4±9.4 years respectively. The mean preoperative weight was 138.2±25 kg in females and 168.8±37.8 kg in males. The mean BMI was similar with 52.4±10.98 kg/m2 in males and 51.4±8.7 kg/m2 in females. In males, as BMI increased, there was an overall decrease in testosterone (10.6±6.307 nmol/L in BMI 30–40 kg/m2, 6.471±3.381 nmol/L in BMI >60 kg/m2) and SHBG (42.075±34.012 in BMI 30–40 kg/m2, 32.1±14.617 nmol/L in BMI >60 kg/m2). In females, as BMI increased, there was an overall increase in testosterone (0.7±0.394 nmol/L in BMI 30–40 kg/m2, 1.1±0.54 nmol/L in BMI >60 kg/m2). In patients with type 2 diabetes, the mean levels of all three hormones in females, and testosterone and oestradiol in males were lower compared to patients without.

Conclusions: The severity of obesity is proportional to gonadal dysfunction, particularly in the reduction in testosterone levels in men.

Keywords: Bariatric surgery; obesity; reproductive hormone levels

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-21-ab110
Cite this abstract as: Ryan MA, Kearns E, Fearon N, McMackin T, Lawton C, O’Reilly P, Heneghan H. SOH21AS201. Reproductive hormone levels in patients with severe obesity undergoing bariatric surgery. Mesentery Peritoneum 2021;5:AB110.

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