AB257. SOH26AB_0321. The role of repeat biopsy in non-diagnostic initial core needle biopsy for soft tissue and bone sarcoma: a systematic review and meta-analysis
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AB257. SOH26AB_0321. The role of repeat biopsy in non-diagnostic initial core needle biopsy for soft tissue and bone sarcoma: a systematic review and meta-analysis

Imad Mirza1, Cian Hehir2, Conor Farrell2, Adil Mirza2, Matthew Lee1, Gary O’Toole1, Alan Molloy1

1Department of Trauma and Orthopaedic Surgery, St. Vincent’s University Hospital, Dublin, Ireland; 2Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland

Background: Core needle biopsy (CNB) has emerged as the biopsy method of choice for suspected soft tissue or bone sarcoma. Though recent literature suggests high diagnostic accuracy and yield, nondiagnostic CNBs often occur. There is a lack of large-scale data on the role of repeat biopsy in this context. Our aim was to assess the role of repeat biopsy, specifically addressing the diagnostic yield using a large data set.

Methods: A systematic search of studies detailing repeat CNB in suspected soft tissue and bone sarcoma was carried out using the MEDLINE, Embase, and PubMed databases. Diagnostic yield and repeat biopsy rate were calculated using random-effect meta-analyses.

Results: A total of nine studies that include almost 9,757 initial CNBs were included in the final analysis. The pooled proportion estimate for the diagnostic yield was 0.691 [95% confidence interval (CI): 0.564–0.819], which indicates a 69% diagnostic yield for repeat CNB following a non-diagnostic initial CNB. With subgroup analyses, a significant difference between the diagnostic yield of repeat CNBs in soft tissue sarcoma (48.5%) and in bone sarcoma (83.1%) was found. Repeat CNB rate following non-diagnostic initial CNB was 5.48%.

Conclusions: This is the first systematic review and meta-analysis that details the role of repeat CNB in non-diagnostic initial CNB in suspected soft tissue or bone sarcoma. Through meta-analysis of almost 10,000 biopsies, a significant difference between the diagnostic yield of repeat CNBs in soft tissue sarcoma (48.5%) and in bone sarcoma (83.1%) was found. Further research focused on repeat biopsy in various subtypes of sarcoma is needed to help further address this clinical dilemma.

Keywords: Biopsy; sarcoma; bone; tumour; orthopaedics

Acknowledgments

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Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-26-ab257
Cite this abstract as: Mirza I, Hehir C, Farrell C, Mirza A, Lee M, O’Toole G, Molloy A. AB257. SOH26AB_0321. The role of repeat biopsy in non-diagnostic initial core needle biopsy for soft tissue and bone sarcoma: a systematic review and meta-analysis. Mesentery Peritoneum 2026;10:AB257.

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