AB221. SOH26AB_0297. Single-centre study of re-excision rates and associated factors in breast-conserving surgery
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AB221. SOH26AB_0297. Single-centre study of re-excision rates and associated factors in breast-conserving surgery

Esther Man Yu Lim1, Francesca Morris1, Sarah Man Lin Lim2, Hugo Serra-Pereira1, Mubashra Badar1, Alaa Alkhamis1, Aidan Manning1, Gerry O’Donoghue1, James Oliver Murphy1

1Department of Breast Surgery, University Hospital Waterford, Waterford, Ireland; 2Department of Radiology, Southampton General Hospital, Southampton, UK

Background: Breast-conserving surgery (BCS) has been shown to provide survival outcomes comparable to mastectomy. Achieving negative surgical margins is essential to reduce the risk of ipsilateral breast tumour recurrence. The American Society of Breast Surgeons (ABS) defines negative margins as <2 mm, “no tumour on ink” for invasive carcinoma and ≥2 mm for ductal carcinoma in situ (DCIS). This study aimed to evaluate factors associated with re-excision following BCS.

Methods: We conducted a retrospective review of all breast cancer patients who underwent BCS at a single centre between October 2022 and December 2024. Variables assessed included the use of cavity shaving, tumour size, the pathological-to-radiological tumour size ratio (PRR), presence of invasive lobular carcinoma (ILC), use of image guidance, and multifocality.

Results: A total of 179 patients were included. Of these, 28 (15.6%) required re-excision. Cavity shaving (P=0.369), tumour size (P=0.296), PRR (P=0.291), ILC (P=0.882), and image guidance (P=0.46) were not significantly associated with re-excision rates. Multifocality was the only factor that demonstrated a significant association (P<0.001).

Conclusions: University Hospital Waterford’s re-excision rate of 15.6% is consistent with reported international averages of approximately 20%. Multifocality was the only factor associated with higher re-excision rates. These findings raise important considerations regarding whether wider margins should be targeted in cases of multifocal disease and highlight the need to improve radiological detection of multifocality.

Keywords: Breast-conserving surgery (BCS); general surgery; margin; multifocality; re-excision

Acknowledgments

None.

Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-26-ab221
Cite this abstract as: Lim EMY, Morris F, Lim SML, Serra-Pereira H, Badar M, Alkhamis A, Manning A, O’Donoghue G, Murphy JO. AB221. SOH26AB_0297. Single-centre study of re-excision rates and associated factors in breast-conserving surgery. Mesentery Peritoneum 2026;10:AB221.

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