AB108. SOH26AB_0185. Association between clinical frailty score, body anthropometric measures, and clinical outcomes in colorectal cancer patients
General Session II

AB108. SOH26AB_0185. Association between clinical frailty score, body anthropometric measures, and clinical outcomes in colorectal cancer patients

Stephen O’Brien, Vivienne Curran, Shane Killeen, Derek Power, Michael O’Riordain

Department of Surgery, Mercy University Hospital, Cork, Ireland

Background: Despite advances in perioperative care, colorectal cancer remains associated with substantial morbidity and mortality. Frailty and adverse body composition are recognised predictors of poor surgical outcomes. This study aimed to examine the association between anthropometric measurements, frailty, and clinical outcomes in colorectal cancer patients.

Methods: Prospective patients were recruited over 12 months in an Irish university hospital. Demographics, comorbidities, and handgrip strength were recorded. Charlson comorbidity index (CCI) and clinical frailty score (CFS) were calculated. Skeletal muscle index and attenuation were measured from staging computed tomography (CT) scans. Logistic regression identified factors associated with postoperative complications and readmissions; linear regression assessed length of stay; Cox-regression analysis assessed recurrence-free and overall survival.

Results: Eighty-eight patients were included (67% male; median age, 68 years). Eleven (12%) were frail (CFS ≥4) and 83% had a CCI ≥4. Thirty-two (36%) were myopenic, 25 (28%) myosteatotic, and 7 (8%) sarcopenic. Frailty did not differ by body composition status, and tumour characteristics and treatment approaches were similar across groups. CFS was associated with increased risk of Clavien-Dindo ≥ 2a complications and 90-day readmission [odds ratio (OR) =5.06; 95% confidence interval (CI): 1.02–25.19]. Myopenia was associated with Clavien-Dindo ≥ 2a complications and 30-day readmission (OR =2.85; 95% CI: 1.10–7.38). While myosteatosis and sarcopenia were not independently associated with complications, both correlated with 90-day readmission as continuous variables. CFS and myosteatosis were associated with increased length of stay (P<0.01). No differences were observed in recurrence-free or overall survival.

Conclusions: Frailty and poor body composition are common in colorectal cancer and are associated with adverse short-term outcomes. These measures, obtainable from routine preoperative assessment and CT imaging, may support early risk stratification and targeted prehabilitation.

Keywords: Colorectal cancer; survival; sarcopenia; myopenia; myosteatosis

Acknowledgments

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Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-26-ab108
Cite this abstract as: O’Brien S, Curran V, Killeen S, Power D, O’Riordain M. AB108. SOH26AB_0185. Association between clinical frailty score, body anthropometric measures, and clinical outcomes in colorectal cancer patients. Mesentery Peritoneum 2026;10:AB108.

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