AB044. SOH26AB_0215. Comparing Oncotype DX recurrence scores and breast density in a single retrospective study of 209 patients undergoing breast cancer surgery
Clinical Breast Session

AB044. SOH26AB_0215. Comparing Oncotype DX recurrence scores and breast density in a single retrospective study of 209 patients undergoing breast cancer surgery

Nnabuike Eneh, Aindrias Lyons, Cillian Mahony, Donal Peter O’Leary

Department of Surgery, Bons Secours Cork, Cork, Ireland

Background: Breast density is a recognised risk factor for breast cancer development. The Oncotype DX (diagnosis) recurrence score provides genomic insight and is used to guide adjuvant treatment decisions. This study aimed to explore whether an association exists between breast density and genomic features in patients undergoing breast cancer surgery.

Methods: A retrospective cohort study was performed on suitable patients who underwent breast cancer surgery between 2020 and 2023 at a single institution. Clinical, radiological, and histopathological data were collected through a chart review and electronic records. Breast density was auto-assessed on pre-operative mammograms and graded using the Breast Imaging-Reporting and Data System (BI-RADS) classification. Associations between breast density and Oncotype DX recurrence score were analysed using univariate and multivariable regression.

Results: A total of 209 patients met the inclusion criteria. Mean recurrence scores differed across density categories, with the highest mean score observed in category A (28.3) and lower scores in categories B–D. Univariate analysis identified an inverse association between breast density and recurrence score (P=0.06). Multivariable regression demonstrated that breast density remained significantly associated with the recurrence score after adjusting for age, family history, and relevant clinicopathological variables (P=0.03). The model’s adjusted R2 improved from 0.425 to 0.657 with the inclusion of breast density.

Conclusions: Breast density is an independent factor associated with the Oncotype DX recurrence score. These findings support a potential radiogenomic relationship between mammographic features and tumour biology, with implications for risk stratification and personalised treatment planning.

Keywords: Breast density; radiogenomics; breast cancer; genomics; recurrence risk

Acknowledgments

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Footnote

Funding: None.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/map-26-ab044
Cite this abstract as: Eneh N, Lyons A, Mahony C, O’Leary DP. AB044. SOH26AB_0215. Comparing Oncotype DX recurrence scores and breast density in a single retrospective study of 209 patients undergoing breast cancer surgery. Mesentery Peritoneum 2026;10:AB044.

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