TY  - JOUR
AU  - Keating, Niamh
AU  - Harding, Tim
AU  - Rothwell, Jane
AU  - Evoy, Denis
AU  - McCartan, Damian
AU  - Prichard, Ruth
AU  - Boland, Michael
PY  - 2026
TI  - AB231. SOH26AB_0427. Margin positivity in breast-conserving surgery after neoadjuvant therapy: a systematic review and meta-analysis
JF  - Mesentery and Peritoneum; Vol 10 (April 30, 2026): Mesentery and Peritoneum  (Abstracts for the Sylvester O'Halloran Perioperative Symposium 2026)
Y2  - 2026
KW  - 
N2  - The role of neoadjuvant systemic therapy (NAST) in the management of breast cancer has expanded dramatically over recent decades. By reducing tumour burden, NAST promotes the feasibility of breast-conserving surgery (BCS) and has the potential to reduce the morbidity of extensive axillary surgery. Across published studies, reported rates of margin positivity after BCS in the post-NAST setting vary, reflecting discrepancies in margin definitions, pathological assessment, and patterns of treatment response. This variability underscores the need for a robust synthesis of the available evidence. This systematic review and meta-analysis aimed to quantify margin positivity rates after NAST and additionally to identify factors associated with positive margins.
UR  - https://map.amegroups.org/article/view/11200